I remember Mickey getting angry and blowing up at Morty and Ferdy several times, in The Mickey Mouse Gottfredson Strip, during the mid 1930s through the 1940s, and even later, with just Morty, in the early 1950s, in "domestic" strips or short stories between Mickey's adventures. But I can't recall the actual stories, or even the circumstances of The Nephews' mischief. I don't specifically recall Mickey getting angry in any of the Paul Murry stories. But I have the faint recollection of his having yelled at Morty and Ferdy and Pluto in a couple different short comic book "filler" stories.
After a while, though, Goofy proves to be so sloppy and irresponsible that it annoys Mickey to the point he ends up yelling at him and they begin physically fighting!
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